If the external host adapter is not ICD compatible this is compensated for by SCSI2Pi. Therefore there are no restrictions with respect to drive capacities und all SCSI commands are available.

The internal host adapter of the MegaSTE has several limitations: It only supports a single ID and can only access the first gigabyte of a drive. For HDDRIVER setups with SCSI2Pi, PiSCSI or BlueSCSI these limitations are a thing of the past. You can add up to 8 devices to the MegaSTE's host adapter. Hard drives, CD-ROM drives and a real-time clock with daylight saving time support, for instance. This is possible because for HDDRIVER supports 8 LUNs (SCSI sub-units), which can easily be created with SCSI2Pi. Except for a Raspberry Pi and the PiSCSI board or BlueSCSI, resp., no special hardware is required.

With SCSI2Pi LUNs are defined by appending the LUN number to the device ID, separated by a colon, e.g.:

>s2p -i 0:0 BOOT_DRIVE_FILE_FOR_LUN_0.hds -i 0:1 CD_ROM.iso -i 0:7 services

Note that the ACSI bus only supports the LUNs 0-7.

A Raspberry Pi Zero WH or Zero 2 W with PiSCSI board can easily be placed inside the MegaSTE instead of a hard drive. The time a MegaSTE with TOS 2.06 waits before trying to boot is sufficient to launch the SCSI2Pi service on an internally mounted Raspberry Pi.
Before switching off the MegaSTE the Pi can be shut down with the SCSI Control app or with the SCSI2Pi client tools. These tools also allow to use SCSI2Pi as realtime clock with daylight saving time support. This is useful, for instance, when the battery of the MegaSTE's clock is empty, or just to have daylight saving time support.

The screenshot shows 6 devices emulated by SCSI2Pi at the internal MegaSTE host adapter.

Important to know: The DaynaPort drivers for STiNG and MiNT unfortunately only supports LUN 0. This means that the DaynaPort emulation cannot be used with the internal host adapter of the MegaSTE in case LUN 0 is already being used by an emulated hard drive. (TOS can only boot from LUN 0.)
It should not be a big deal to extend the DaynaPort drivers with LUN support. On GitHub there is code for the SCSI Driver, which automatically detects a particular device independent of its SCSI ID or LUN.